The following is a full listing of the cast for the episode "4 Years, 6 Months, 2 Days".
- Chad Michael Murray as Lucas Scott
- James Lafferty as Nathan Scott
- Hilarie Burton as Peyton Sawyer
- Bethany Joy Lenz as Haley James Scott
- Sophia Bush as Brooke Davis
- Lee Norris as Mouth McFadden
- Antwon Tanner as Antwon "Skills" Taylor
- Jackson Brundage as Jamie Scott
- Vaughn Wilson as Fergie Thompson
- Cullen Moss as Junk Moretti
- Lisa Goldstein as Millicent Huxtable
- Dikran Tulaine as John Knight
Credited Without Appearance
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