The following is a full listing of the cast for the episode "All of a Sudden I Miss Everyone".
- Chad Michael Murray as Lucas Scott
- James Lafferty as Nathan Scott
- Hilarie Burton as Peyton Sawyer
- Bethany Joy Lenz as Haley James Scott
- Paul Johansson as Dan Scott
- Sophia Bush as Brooke Davis
- Barbara Alyn Woods as Deb Scott
- Lee Norris as Mouth McFadden
- Antwon Tanner as Antwon "Skills" Taylor
- Danneel Harris as Rachel Gatina
- Barry Corbin as Whitey Durham
- Moira Kelly as Karen Roe
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