The following is a full listing of the cast for the episode "Family Affair".
- James Lafferty as Nathan Scott
- Bethany Joy Lenz as Haley James Scott
- Sophia Bush as Brooke Davis
- Austin Nichols as Julian Baker
- Robert Buckley as Clayton Evans
- Shantel VanSanten as Quinn James
- Jackson Brundage as Jamie Scott
- Lee Norris as Mouth McFadden
- Jana Kramer as Alex Dupre
- Lisa Goldstein as Millicent Huxtable
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