{{Sectionbox Family|name =
[[Peyton Sawyer
]]|color = lightgreen|image = Leyton.jpg|Relationship = Wife|Details = Lucas has been in love with Peyton since his childhood but she was dating his brother. After they broke up Peyton and Lucas had a complicated relationship/ friendship. In Season 4 Peyton admits to Lucas that she loves him, overwhelmed and shocked he says "oh" but after the State Championship he has a moment of clarity and he realises he wants to be with Peyton. After graduation Lucas visits Peyton in LA and he proposes to her, she refuses. After Lucas almost marries another girl, Lindsey Stauss, he chooses Peyton and that get engaged in Las Vegas. Peyton finds out she's pregnant and Lucas and Peyton find out Peyton has Placenta Previa meaning she could die if she had the baby. Peyton has the baby anyway and after she is born Peyton and Lucas leave Tree Hill.}}{{Sectionbox Family|name =
[[Sawyer Scott
]]|color = lightgreen|image = 624_l_wit_ss.jpg|Relationship = Daughter|Details = Lucas Scott is the loving father of Sawyer Scott. Originally uncertain about whether to keep the child, due to the life of his wife being at risk, Lucas soon took to the idea of being a father and aims to be a father like his uncle, Keith Scott, was to him. During his wife's pregnancy, Lucas created a nursery for his child to surprise his wife. After Sawyer was born, Lucas and his family departed Tree Hill to start a new life with their new family.}}{{Sectionbox Family|name =
[[Karen Roe
]]|color = lightgreen|image = Karen&Lucas.jpg|Relationship = Mother|Details = Karen
raised Lucas
alone after being abandoned by Dan after she got pregnant. They have a
very close relationship
. Lucas does feel guilty at times that she has sacrificed so much to
provide for him but she always insists that she would not change a thing. Lucas
was thus always supportive of Karen having her own
life and her own dreams as well as a relationship of her own.
Though he had always
clearly hoped she would end up with Keith, fate had other plans. He helped her as much as he
could when Lily was born. After the birth of
his own child, he and Peyton escaped the
drama and history of Tree Hill to travel with Lily, Karen and her
new husband.}}{{Sectionbox Family|name =
[[Keith Scott
]]|color = lightgreen|image = Keith&Lucas.jpg|Relationship = Uncle|Details =
When Dan abandoned Karen, Keith stepped up and
became the needed father figure
in Lucas' life. Because he loved both of he was willing to
put his
own dreams and plans on hold to support them. Lucas worked
after school at Keith
's Auto Shop. It was through that job that Lucas had his
first fateful conversation with his long-time crush and
future wife Peyton Sawyer. Though they were estranged for a
time over the whole Jules fiasco. When Karen and
Keith got engaged and he planned to adopt Lucas
. All his childhood dreams seemed to be coming true, but
it ended tragically when Keith made the ultimate sacrifice to protect Lucas during the school shooting. It was the most painful event of Lucas' life and permanently destroyed his relationship with Dan when the truth was revealed. Lucas honored him the best way he
knew how, by becoming the type of man Keith raised him to be. He kept Keith's ring so so he
could give it to
the woman he would spend the rest of his life with.}}{{Sectionbox Family|name =
[[Nathan Scott
]]|color = lightgreen|image = Lucas&Nathan.jpg|Relationship = Half-Brother|Details = Lucas and Nathan are Half-Brothers, Same father different
mothers. At first they didn't like each other
. They did not interact much until Lucas joined the basketball team. Dan encouraged Nathan to make Lucas' life miserable and drive him from the team so he would not be a threat to his position. It didn't work, and once Nathan started
dating Haley he truly changed his ways. Lucas was one of the few to fully support his young marriage to Haley from the start, viewing Nathan as his true brother and
knowing their love was the real deal.
Mostly they had a great relationship past that point. He was supportive of him when Haley left on tour, though he objected when Nathan gave her the cold shoulder for a time after her return. When Nathan and Haley went to a small college Lucas moved in with them to help raise their son Jaime. Even though it proved to be costly to his own personal life. He chose Nathan as his best man for both his weddings}}{{Sectionbox Family|name =
[[Jamie Scott
]]|color = lightgreen|image = 907OneTreeHill1144.jpg|Relationship = Nephew/ Godson|Details = Lucas was both Jamie's uncle and godfather. Jamie was born shortly after the death of Lucas' uncle Keith with whom he had a very strong relationship with. Due to this Lucas tried to be like Keith. And during Jamie's
early years when his parents were in college Lucas helped to raise Jamie. And when Nathan was diagnosed with depression after his accident he stepped up even more. But after Lucas' daughter was born Lucas and his family started to travel the world, so Jamie didn't see Lucas as much as he wanted although they did remain in contact.}}{{Sectionbox Family|name =
[[Lydia Scott
]]|color = lightgreen|image = lylu907.jpg|Relationship = Niece|Details = Due to Peyton and Lucas leaving before Lydia was born they don't know each other that well, but Lucas and Peyton took care of Jamie and Lydia when Haley was looking for Nathan.}}{{Sectionbox Family|name =
[[Haley James
]]|image = 907OneTreeHill1105.jpg|Relationship = Sister-in-law|Details = Haley and Lucas were best friends
since childhood, considering themselves social outcasts up until junior year of High School. Their relationship was never anything but platonic. When Haley
first got involved with Nathan
, it threatened to drive a wedge between them as the brothers were bitter rivals at the time. But Haley brought out the best in Nathan. It was through her that they became
close friends and true brothers. After getting over the shock, Lucas was fully supportive of their marriage, knowing their love was true. He remained Haley's closest friend and supporter even when others were turning their backs on her. After they left school Lucas put his own dreams on hold to help them raise Jaime, much as his own uncle had done for him. Even after leaving Tree Hill. Lucas returned to offer help and moral support when Nathan went missing.|color = lightgreen}}{{Sectionbox Family|name =
[[Dan Scott
]]|color = lightgreen|image = Dan&Lucas.jpg|Relationship = Father|Details = Dan
was Lucas'
biological father but
abandoned him before he
was even born. He and no role in the first 16 years of his life
. But when Lucas joined the basketball team and
threatened to usurp Nathan's position, he turned the two against each other. Despite this the brothers formed a close relationship. They got along better after
Dan's heart attack and Lucas
even moved into Dan's house for
a time. Lucas was relying on Dan to keep
secret the fact that they shared the same potentially fatal heart condition.
As it turned out each was plotting against the
other, a game Dan won in the end. But despite this, Lucas
risked his life pulling Dan out of the fire at the dealership, a choice he regretted many times since. The two did not truly repair their relationship until until after Keith death. When Dan was making a serious effort to atone for his past mistakes. But when Lucas discovered the truth about Keith'
s murder it destroyed their relationship forever. Lucas was notably the only close family member who refused to
accept he had changed or to visit Dan when he was dying, something Dan understood completely.}}{{Sectionbox Family|name =
[[Lily Roe Scott
]]|color = lightgreen|image = 513OneTreeHill0776.jpg|Relationship = Half-
Sister/ Cousin|Details = Lily is the daughter of Keith and Karen and they are very close, after Peyton and Lucas had Sawyer they left to travel the world with Karen, Andy and Lily.}}